What is the clinical evidence from this study?

Study design: Systematic Review. Population: Suspected bleeding disorders. Intervention: Platelet function testing.

What question did this study set out to answer?

Provide healthcare professionals with evidence-based guidance on performing and interpreting laboratory platelet function tests for individuals with suspected inherited bleeding disorders.

July 26, 2011British Journal of HaematologyOpen Access

Guidelines for the laboratory investigation of heritable disorders of platelet function

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Population

Patients with suspected bleeding disorders

Design

Guideline

Authors

PHPaul HarrisonCross-Cutting Cardiology IMIan MackieUniversity College London AMAndrew MumfordCross-Cutting Cardiology

Discussion

Member takes

Implication

UK guidelines now standardize lab evaluation of suspected heritable platelet disorders; extends prior expert consensus into actionable protocols.

Key Points

Provide healthcare professionals with evidence-based guidance on performing and interpreting laboratory platelet function tests for individuals with suspected inherited bleeding disorders.
Conducted a systematic search of MEDLINE through Summer 2010 focused on platelet function testing and aggregometry, augmented by reviews of relevant reference lists and existing guidelines.
Drafted recommendations via a UK expert writing group with iterative consensus revisions and input from the BCSH Haemostasis and Thrombosis Task Force.
Evaluated draft guidance through an external sounding board of approximately 40 UK haematologists, grading evidence in accordance with BCSH procedural criteria.
Established standardized clinical consensus protocols for selecting and interpreting platelet function testing, emphasizing the central role of platelet aggregometry.
Determined that standard evaluation frameworks may not generalize to individuals receiving antiplatelet therapy, necessitating individualized clinical assessment.

Study Design

Type

Systematic Review

Structured PICO

Population

Patients with suspected bleeding disorders

Intervention

Laboratory investigation and platelet function testing

Provides UK guidelines for the laboratory investigation of heritable disorders of platelet function.

Limitations

The guidance may not be appropriate to patients receiving antiplatelet therapy
Individual patient circumstances may dictate an alternative approach

Cite This Study

Harrison et al. (2011) conducted a systematic review in Suspected bleeding disorders. Platelet function testing was evaluated. Platelet function testing guidelines were developed by UK experts to provide clear guidance for the laboratory investigation of patients with suspected heritable bleeding disorders.

synapsesocial.com/papers/6a178b905fdf2a7b88aa1f44 https://doi.org/10.1111/j.1365-2141.2011.08793.x

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Implication

UK guidelines now standardize lab evaluation of suspected heritable platelet disorders; extends prior expert consensus into actionable protocols.

Guidelines for the laboratory investigation of heritable disorders of platelet function

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Guidelines for the laboratory investigation of heritable disorders of platelet function

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider