Prevention and treatment of anthracycline-induced cardiotoxicity: a systematic review and network meta-analysis of randomized controlled trials

Fig. 1. Research screening process

Fig. 2. Network of LVEF. Note: DEX: Dexrazoxane; GSH: Reduced glutathione; GIK: Glucose-insulin-potassium. Astragalus, Astragalus polysaccharide, Coix Seed Oil, Compound salvia miltiorrhiza, Cinobufacini, Danshen, Diosgenin, Kushen, Platycodon grandiflorum, Qiliqiangxin, Safflower, Safflower yellow, Saffron total glycoside, Shengmai, Shenmai, Shenqi Fuzheng, Shexiang Baoxin, Xinmai Long, and Yiqi Fumai are Chinesel Patent Medicines, and most are injections (Diosgenin, Platycodon grandiflorum, Qiliqiangxin, Saffron total glycoside, and Shexiang Baoxin are solid oral dosage forms, including tablets, pills, capsules, and granules)

Fig. 3. Network forest plot of LVEF. Note: DEX: Dexrazoxane; GSH: Glutathione; GIK: Glucose-insulin-potassium. Astragalus, Astragalus polysaccharide, Coix Seed Oil, Compound salvia miltiorrhiza, Cinobufacini, Danshen, Diosgenin, Kushen, Platycodon grandiflorum, Qiliqiangxin, Safflower, Safflower yellow, Saffron total glycoside, Shengmai, Shenmai, Shenqi Fuzheng, Shexiang Baoxin, Xinmai Long, and Yiqi Fumai are Chinese Patent Medicines, and most are injections (Diosgenin, Platycodon grandiflorum, Qiliqiangxin, Saffron total glycoside, and Shexiang Baoxin are solid oral dosage forms, including tablets, pills, capsules, and granules)

Fig. 4. Network forest plot of electrocardiographic abnormalities. Note: DEX: Dexrazoxane; GSH: Glutathione; GIK: Glucose-insulin-potassium. Astragalus, Compound salvia miltiorrhiza, Cinobufacini, Diosgenin, Ginkgo Leaf Extract and Dipyridamole, Kushen, Platycodon grandiflorum, Safflower, Safflower yellow, Saffron total glycoside, Shenfu, Shengmai, Shenmai, Shenqi Fuzheng, Shuxuening, Shensong Yangxin, Xinmai Long, Zhenqi Fuzheng, and Zhenyuan are Chinese Patent Medicines, and most are injections (Diosgenin, Platycodon grandiflorum, Saffron total glycoside, Shensong Yangxin, Zhenqi Fuzheng, and Zhenyuan are solid oral dosage forms, including tablets, capsules, and granules)

Fig. 5. Network forest plot of CK-MB. Note: DEX: Dexrazoxane; GSH: Glutathione. Astragalus, Astragalus polysaccharide, Cinobufacini, Danshen, Kushen, Saffron total glycoside, Shenfu, Shenmai, Shenqi Fuzheng, Shuxuening, Yiqi Fumai, and Zhenqi Fuzheng are Chinese Patent Medicines, and most are injections (Saffron total glycoside, and Zhenqi Fuzheng are solid oral dosage forms, including tablets and granules)

Fig. 6. Network forest plot of symptomatic cardiotoxicity. Note: DEX: Dexrazoxane; GIK: Glucose-insulin-potassium. Astragalus, Astragalus polysaccharide, Coix Seed Oil, Compound salvia miltiorrhiza, Cinobufacini, Danshen, Diosgenin, Kudiezi, Kushen, Platycodon grandiflorum, Saffron total glycoside, Shenfu, Shengmai, Shenmai, Shenqi Fuzheng, SuXiaoJiuXinWan, Xinmai Long, Yiqi Fumai, and Zhenyuan are Chinese Patent Medicines, and most are injections (Diosgenin, Platycodon grandiflorum, Saffron total glycoside, SuXiaoJiuXinWan, and Zhenyuan are solid oral dosage forms, including tablets, capsules, and granules)