Key result
Altered metabolic pathways and COVID-19 hypercoagulability contribute to VTE pathogenesis.
Why the study?
Recent innovations in venous thromboembolism include discoveries on biomarkers, metabolomics, and COVID-19-related hypercoagulability, but a review bringing together these recent lines of evidence was lacking.
This review synthesizes recent evidence on the role of metabolomics, biomarkers, and COVID-19-induced hypercoagulability in the pathogenesis of venous thromboembolism.
Answers are grounded in this paper and cite their sources.
Does not alter VTE management in COVID-19; leaves open metabolic pathways for prospective validation.
In recent years, the field of venous thromboembolism has undergone numerous innovations, starting from the recent discoveries on the role of biomarkers, passing through the role of metabolomics in expanding our knowledge on pathogenic mechanisms, which have opened up new therapeutic targets. A variety of studies have contributed to characterizing the metabolic phenotype that occurs in venous thromboembolism, identifying numerous pathways that are altered in this setting. Among these pathways are the metabolism of carnitine, tryptophan, purine, and fatty acids. Furthermore, new evidence has emerged with the recent COVID-19 pandemic. Hypercoagulability phenomena induced by this viral infection appear to be related to altered von Willebrand factor activity, alteration of the renin-angiotensin-aldosterone system, and dysregulation of both innate and adaptive immunity. This is the first literature review that brings together the most recent evidence regarding biomarkers, metabolomics, and COVID-19 in the field of venous thromboembolism, while also mentioning current therapeutic protocols.
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Corte et al. (2023) conducted a review in Venous thromboembolism. A literature review highlights the role of altered metabolic pathways and COVID-19-induced hypercoagulability in the pathogenesis of venous thromboembolism.
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