Key result
01BSUR reduces atherosclerotic plaque burden by ~37% on elastin-targeted MRI in mice.
Why the study?
Does 01BSUR reduce plaque burden in male apolipoprotein E-deficient mice on a high-fat diet?
Does 01BSUR reduce plaque burden in male apolipoprotein E-deficient mice on a high-fat diet?
Answers are grounded in this paper and cite their sources.
An elastin-targeted MRI probe can quantify the therapeutic effects of the anti-interleukin-1β monoclonal antibody 01BSUR, which hinders atherosclerosis progression in a mouse model.
Atherosclerosis is a chronic inflammatory condition of the arteries and represents the primary cause of various cardiovascular diseases. Despite ongoing progress, finding effective anti-inflammatory therapeutic strategies for atherosclerosis remains a challenge. Here, we assessed the potential of molecular magnetic resonance imaging (MRI) to visualize the effects of 01BSUR, an anti-interleukin-1β monoclonal antibody, for treating atherosclerosis in a murine model. Male apolipoprotein E-deficient mice were divided into a therapy group (01BSUR, 2 × 0.3 mg/kg subcutaneously, n = 10) and control group (no treatment, n = 10) and received a high-fat diet for eight weeks. The plaque burden was assessed using an elastin-targeted gadolinium-based contrast probe (0.2 mmol/kg intravenously) on a 3 T MRI scanner. T1-weighted imaging showed a significantly lower contrast-to-noise (CNR) ratio in the 01BSUR group (pre: 3.93042664; post: 8.4007067) compared to the control group (pre: 3.70679168; post: 13.2982156) following administration of the elastin-specific MRI probe (p < 0.05). Histological examinations demonstrated a significant reduction in plaque size (p < 0.05) and a significant decrease in plaque elastin content (p < 0.05) in the treatment group compared to control animals. This study demonstrated that 01BSUR hinders the progression of atherosclerosis in a mouse model. Using an elastin-targeted MRI probe, we could quantify these therapeutic effects in MRI.
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Mangarova et al. (2024) studied Atherosclerosis (n=20). 01BSUR vs. no treatment was evaluated on contrast-to-noise (CNR) ratio following administration of the elastin-specific MRI probe (p=< 0.05). 01BSUR significantly reduced plaque burden in a mouse model of atherosclerosis, demonstrated by a lower contrast-to-noise ratio on elastin-targeted MRI compared to control (8.4 vs 13.3; p < 0.05).
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