Key result
Genetic variants tied to adipocyte function and metabolism are linked to weight gain and visceral obesity.
Why the study?
Obesity and its associated diseases have a high worldwide prevalence, with changes in the structure and functional activity of genes encoding adipocytokines contributing to genetic predisposition to weight gain.
This review summarizes functionally significant genetic variants associated with adipocyte function, metabolic aberrations, and visceral obesity.
Answers are grounded in this paper and cite their sources.
Supports targeted genetic research in visceral obesity; insufficient evidence for clinical practice changes.
The high prevalence of obesity and of its associated diseases is a major problem worldwide. Genetic predisposition and the influence of environmental factors contribute to the development of obesity. Changes in the structure and functional activity of genes encoding adipocytokines are involved in the predisposition to weight gain and obesity. In this review, variants in genes associated with adipocyte function are examined, as are variants in genes associated with metabolic aberrations and the accompanying disorders in visceral obesity.
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Bairqdar et al. (2023) conducted a review in Abdominal Obesity. Genetic variants associated with adipocyte function and metabolic aberrations play a significant role in the predisposition to weight gain and visceral obesity.
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