Why the study?
Do changes in dietary sodium cause different renal hemodynamic responses in black versus white males with essential hypertension?
Population
81 untreated, age-matched, and blood pressure-matched white and black males with essential hypertension
Comparison
High salt diet for 5 days vs Low salt diet for 5 days
Design
Cohort
Follow-up
5 days each of high and low salt diets
Authors
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May explain racial disparities in hypertensive nephropathy; extends prior observations but remains hypothesis-generating.
Do changes in dietary sodium cause different renal hemodynamic responses in black versus white males with essential hypertension?
Black males with essential hypertension exhibit glomerular hyperfiltration in response to high dietary sodium, suggesting a potential mechanism for racial disparities in hypertension-related renal disease.
Parmer et al. (1994) studied this question.