Key result
In an urban Indian adult population with primary hypertension, 38.4% of patients were prescribed calcium channel blockers alone and 30.0% were on a combination of calcium channel blockers and beta blockers.
Cross-Sectional (n=1,081)
No
A significant proportion of hypertensive patients in this urban Indian cohort were prescribed beta-blockers without adequate indications, highlighting a therapeutic lag between current practice and recent international guidelines.
Suggests guideline-practice gap in urban Indian hypertension; hypothesis-generating and should not yet change practice.
As of 2016, An estimated 180 million people in India have primary hypertension. We set out to investigate the pharmacotherapeutic profile in this vast and varied population. Our objective was to assess what fraction of our study population was on medication in accordance to the best available contemporary medical evidence by comparing our results with 05 International guidelines published in the past 06 years. Methods: We studied 1081 patients with a previous diagnosis of primary hypertension and analyzed the antihypertensives they were on, which had been prescribed from various urban and rural centers. Some of these patients were on our follow up as outpatients, while others were migrating from other medical setups. It was our endeavor to study a sample size large enough so that extrapolation to the general population was not an obstacle. Results: Of the 1081 patients studied, 38.4% (35.5 -41.3 with 95% CI) were on calcium channel blockers alone, 30.0 % (27.2 -32.7 with 95% CI) were on a combination of calcium channel blockers and beta blockers, 14.1 % (12.09 -16.25 with 95% CI) were on diuretics alone, 15. 09% (12.96 -17.23 with 95% CI) and 2.31 % (1.42 -3.21 with 95% CI) were on other medication which includes beta blockers alone, alpha blockers alone and vasodilators.
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Mujeeb et al. (2017) conducted a cross-sectional in Primary hypertension (n=1,081). Antihypertensive pharmacotherapy was evaluated on Proportion of patients on calcium channel blockers alone (95% CI 35.52-41.33). In an urban Indian adult population with primary hypertension, 38.4% of patients were prescribed calcium channel blockers alone and 30.0% were on a combination of calcium channel blockers and beta blockers.
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