Key result
In patients with mild dynamic subaortic stenosis, the Valsalva maneuver significantly increased the murmur's peak frequency from 324 Hz at rest to 453 Hz, revealing a characteristic late systolic peak.
Why the study?
Does a novel graphic display of heart sounds identify characteristic spectral patterns in patients with dynamic subaortic stenosis?
Observational (n=31)
No
Does a novel graphic display of heart sounds identify characteristic spectral patterns in patients with dynamic subaortic stenosis?
A novel portable graphic display of heart sounds can reliably identify the characteristic late-peaking, high-frequency spectral pattern of dynamic subaortic stenosis, potentially aiding in early detection and screening.
May facilitate noninvasive identification of dynamic subaortic stenosis; leaves open prospective validation for screening.
Background: Dynamic subaortic stenosis occurs in differing situations, commonly with hypertrophic cardiomyopathy. Regardless of the underlying cause, the resulting murmurs usually possess a characteristic sound spectral pattern, manifesting a sharp and high frequency peak occurring late in systole, often bearing a striking resemblance to the subaortic Doppler flow pattern. Methods: Murmurs found in thirty one subjects with dynamic subaortic stenosis were analyzed after having been recorded with a novel portable device capable of spectral and waveform sound displays. Results: All subjects manifested characteristic frequency patterns, consisting of high and sharp peaks occurring in late systole. With significant subaortic stenosis (resting subaortic flow velocity > 2 m/sec) this pattern was evident at rest. In the presence of little or no resting subaortic obstruction (< 2 m/sec) this pattern was produced regularly by the Valsalva maneuver. Conclusions: Dynamic subaortic stenosis produces a specific sound spectral pattern that may provide a basis for clinical evaluation, especially in early detection of this disorder and in screening situations.
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Morton E. Tavel (2012) conducted an observational in Dynamic subaortic stenosis (n=31). Valsalva maneuver vs. Rest was evaluated on Peak frequency (Hz) in patients with low resting subaortic peak velocity (<2 m/s) (p=<0.0001). In patients with mild dynamic subaortic stenosis, the Valsalva maneuver significantly increased the murmur's peak frequency from 324 Hz at rest to 453 Hz, revealing a characteristic late systolic peak.
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