What does this research mean for the field?

Long-term beta blockade therapy produces sustained improvement in exercise capacity and reduces symptoms of dyspnea and chest pain in patients with hypertrophic cardiomyopathy, with the greatest benefit observed in those with the least initial impairment. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 2, 1983European Heart Journal

Long-term medical management of hypertrophic cardiomyopathy: usefulness of propranolol

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Why the study?

Does beta blockade improve exercise capacity and symptoms in patients with hypertrophic cardiomyopathy?

Population

32 patients with hypertrophic cardiomyopathy (HCM), mean age 47 years, 21 men.

Comparison

Beta blockade adjusted to achieve a standing… vs Baseline (prior to therapy)

Design

Cohort

Authors

MFMartin J. FrankBiognos (Sweden)AAAdam AbdullaRobert Gordon University LWLaurence O. WatkinsUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

May support beta blockade for HCM symptoms; hypothesis-generating and should not yet change practice pending RCTs.

Structured PICO

Does beta blockade improve exercise capacity and symptoms in patients with hypertrophic cardiomyopathy?

Population

32 patients with hypertrophic cardiomyopathy (HCM), mean age 47 years, 21 men.

Intervention

Beta blockade (propranolol, nadolol, or metoprolol) adjusted to achieve a standing heart rate of 60 beats/min.

Comparator

Baseline (prior to therapy)

Outcome

Exercise capacity (duration on Bruce protocol and functional aerobic capacity)surrogate

Long-term beta blockade in patients with hypertrophic cardiomyopathy produces sustained improvements in exercise capacity and symptoms.

Cite This Study

Frank et al. (1983) studied this question.

synapsesocial.com/papers/6a17b140a0e670aec86ebc4c https://doi.org/10.1093/eurheartj/4.suppl_f.155

Topics

Hypertrophic cardiomyopathy

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Long-term medical management of hypertrophic cardiomyopathy: usefulness of propranolol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Long-term medical management of hypertrophic cardiomyopathy: usefulness of propranolol

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider