Key result
An automated stimulator using a commercial pressure servo successfully induced premature ventricular excitations in isolated rat hearts similar to those observed in larger hearts.
A commercial pressure servo can be used to study mechanically induced arrhythmias in isolated rat hearts, providing a convenient model for exploring the molecular basis of mechanotransduction.
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Enables rat-heart models for mechanotransduction arrhythmia research; leaves open clinical translation.
Transient stretching of the ventricle can trigger arrhythmias and evoke ventricular fibrillation, especially when the stimulation occurs in the vulnerable period. To explore the sensitivity of small hearts we used a commercial pressure servo to study the kinetic relationship of left ventricular pressure to excitability and arrhythmias in the rat heart. Stimulation protocols were readily composed on the computer and programmed to vary the stimulus amplitude and timing relative to pacing. The pressure-induced premature ventricular excitations were similar to those observed in larger hearts, but the convenience of using small hearts allows the use of inexpensive transgenic animals to explore the molecular basis of transduction.
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Huang et al. (2009) studied Mechanically induced arrhythmias. Automated stimulator (commercial pressure servo) was evaluated on Pressure-induced premature ventricular excitations. An automated stimulator using a commercial pressure servo successfully induced premature ventricular excitations in isolated rat hearts similar to those observed in larger hearts.
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