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This technique provides a model to study antiarrhythmic drug activity at the cellular level by excluding extracardiac factors.
Exposure to isoprenaline plus electrical stimulation of the isolated right ventricle of the rat produces stable ventricular automatic activity of various types. The incidence of these different types of ventricular arrhythmia is tabulated and analysed. The technique allows the antiarrhythmic activity of drugs to be studied at cellular level where extracardiac factors are excluded.
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Jalón et al. (1972) studied this question.
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