August 1, 1996Journal of Applied Physiology
Is respiratory sinus arrhythmia a good index of cardiac vagal tone in exercise?
Why the study?
Does ganglion blockade affect respiratory sinus arrhythmia at rest and during exercise in healthy men?
Population
10 healthy men (mean age 21 +/- 1 yr)
Comparison
Ganglion blockade with trimetaphan camsylate at… vs Before ganglion blockade at rest and during…
Design
Other
Authors
Discussion
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Member takes
Implication
RSA may not index vagal tone during exercise; leaves open nonneural contributions in healthy humans.
Structured PICO
Does ganglion blockade affect respiratory sinus arrhythmia at rest and during exercise in healthy men?
P
Population
10 healthy men (mean age 21 +/- 1 yr)
I
Intervention
Ganglion blockade with trimetaphan camsylate (3-5 mg/min i.v.) at rest and during exercise (steady-state supine cycle ergometry at 25% of peak oxygen uptake)
C
Comparator
Before ganglion blockade (control) at rest and during exercise
O
Outcome
Respiratory sinus arrhythmia (RSA) calculated from the power of the spectral component of the R-R interval variability centered at the breathing frequencysurrogate
As vagal tone decreases with exercise, an increasing proportion of respiratory sinus arrhythmia is driven by nonneural mechanisms, suggesting RSA may not be a pure index of cardiac vagal tone during exercise.
Cite This Study
Casadei et al. (1996) studied this question.