Key result
Plasma MMP-9 and TIMP-2 link to MRI hemodynamics and pulmonary arterial stiffness in pediatric PAH.
Why the study?
Are plasma levels of metalloproteinases and their inhibitors associated with pulmonary arterial stiffness and ventricular function in pediatric pulmonary hypertension?
Observational
Are plasma levels of metalloproteinases and their inhibitors associated with pulmonary arterial stiffness and ventricular function in pediatric pulmonary hypertension?
Peripheral circulating MMP and TIMP levels may serve as biomarkers for assessing extracellular matrix remodeling and hemodynamic status in pediatric PAH.
MMP-9/TIMP-2 levels may indicate remodeling severity in pediatric PAH; hypothesis-generating, requiring prospective validation before biomarker adoption.
Metalloproteinases have been associated with clinical outcomes in pulmonary hypertension and with specific pathological features of ventricular dysfunction and pulmonary arterial remodeling. In this study, we demonstrated that plasma circulating levels of metalloproteinases and their inhibitors are associated with standard cardiac MRI hemodynamic indices and with the markers of proximal pulmonary arterial stiffness. Particularly, MMP-9 and TIMP-2 were associated with several different markers of pulmonary arterial stiffness. These findings suggest the interplay between the extracellular matrix (ECM) remodeling and overall hemodynamic status in children with PAH might be assessed using the peripheral circulating MMP and TIMP levels.
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Schäfer et al. (2021) conducted an observational in pediatric pulmonary hypertension. plasma circulating levels of metalloproteinases and their inhibitors was evaluated on cardiac MRI hemodynamic indices and markers of proximal pulmonary arterial stiffness. Plasma levels of metalloproteinases and their inhibitors, particularly MMP-9 and TIMP-2, were associated with cardiac MRI hemodynamic indices and pulmonary arterial stiffness in children with PAH.
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