What question did this study set out to answer?

To determine whether galectin-3 inhibition using modified citrus pectin alters circulating markers of collagen metabolism in patients with elevated galectin-3 levels and hypertension.

January 1, 2021JACC Basic to Translational ScienceOpen Access

Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension

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Authors

ELEmily LauMassachusetts General Hospital ELElizabeth LiuBeth Israel Deaconess Medical Center SPSamantha M. PaniaguaMassachusetts General Hospital

Discussion

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Implication

Randomized placebo-controlled trial finds modified citrus pectin does not alter collagen markers in hypertension, indicating Gal-3 inhibition needs alternative targets.

Key Points

To determine whether galectin-3 inhibition using modified citrus pectin alters circulating markers of collagen metabolism in patients with elevated galectin-3 levels and hypertension.
Conducted a proof-of-concept randomized placebo-controlled trial in participants with hypertension and elevated galectin-3 levels.
Evaluated cross-sectional relationships between baseline galectin-3 concentrations and participant clinical characteristics.
Higher baseline galectin-3 levels were associated with female sex, diabetes, and reduced glomerular filtration rate in cross-sectional analyses.
Treatment with modified citrus pectin did not significantly alter markers of collagen metabolism compared to placebo.

Cite This Study

Lau et al. (2021) studied this question.

synapsesocial.com/papers/6a17bb30cf49e78c48b46309 https://doi.org/10.1016/j.jacbts.2020.10.006

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Implication

Randomized placebo-controlled trial finds modified citrus pectin does not alter collagen markers in hypertension, indicating Gal-3 inhibition needs alternative targets.

Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

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