Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound

Powder compaction data of three polymorphic Forms I (shearing), II (bending) and III (brittle) of 6-chloro-2,4-dinitroaniline demonstrates a direct relationship among mechanical properties, crystal structure and tableting behaviour, showing the essence of structure based assessment of mechanical properties of crystals, e.g., for identifying more efficient API formulation and manufacture processes.