Key result
A BNP-driven fluid management strategy significantly reduced the median time to successful extubation compared with empirical physician-driven therapy (42.4 vs. 58.6 hours; P=0.034).
Why the study?
Does fluid management guided by daily BNP plasma concentrations reduce time to successful extubation in patients undergoing ventilator weaning?
Population
304 patients undergoing ventilator weaning
Comparison
Fluid management guided by daily B-type… vs Physician-driven strategy of fluid management…
Design
RCT, randomized
Authors
Loading...
Supports BNP-guided fluid management to shorten weaning time; confirms randomized benefit in ventilated patients.
RCT (n=304)
randomized
Yes
Does fluid management guided by daily BNP plasma concentrations reduce time to successful extubation in patients undergoing ventilator weaning?
Absolute Event Rate: 42.4% vs 58.6%
p-value: p=0.034
A BNP-driven fluid management strategy significantly decreases the duration of ventilator weaning without increasing adverse events, particularly in patients with left ventricular systolic dysfunction.
Dessap et al. (2012) conducted an RCT in Difficult weaning from mechanical ventilation (n=304). BNP-driven fluid management vs. Physician-driven fluid management was evaluated on Time to successful extubation (p=0.034). A BNP-driven fluid management strategy significantly reduced the median time to successful extubation compared with empirical physician-driven therapy (42.4 vs. 58.6 hours; P=0.034).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: