Key result
Lowest tertile of platelet aggregation is linked to increased Alzheimer's amyloid and tau PET uptake.
Why the study?
Vascular dysfunction contributes to Alzheimer disease and related dementias, but underlying mechanisms remain unclear, prompting investigation into whether midlife platelet aggregation associates with imaging markers of AD pathology.
Observational (n=382)
No
Answers are grounded in this paper and cite their sources.
Platelet aggregation in midlife is associated with PET and MRI imaging markers of Alzheimer disease pathology, suggesting a potential vascular or thrombotic pathway in early disease pathogenesis.
BACKGROUND AND OBJECTIVES: Vascular dysfunction contributes to Alzheimer disease (AD) and related dementias (ADRDs), but the underlying mechanisms remain unclear. Previous studies link midlife hemostasis and platelet aggregation measures to late-life dementia risk. We aimed to determine whether platelet aggregation in midlife is associated with imaging markers of AD pathology. METHODS: F-flortaucipir) PET uptake in dementia-free, middle-aged adults from the Framingham Heart Study. Co-primary outcomes included amyloid and tau uptake in AD-vulnerable regions. We also examined an MRI-based cortical thickness signature of AD risk as a secondary outcome. We used multivariable regression models adjusted for demographic and clinical factors, considering potential nonlinear associations. DISCUSSION: Our findings indicate that platelet aggregation is linked to PET and MRI markers of AD pathology as early as midlife. These findings support further investigation of platelet-mediated mechanisms in AD pathogenesis.
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Ramos‐Cejudo et al. (2025) conducted an observational in Alzheimer disease pathology markers (n=382). Platelet aggregation vs. Higher platelet aggregation (tertiles/quartiles) was evaluated on Amyloid PET uptake in the precuneus (among participants in the lowest tertile of platelet aggregation) (β = 0.047 (SE 0.020), p=0.020). In dementia-free middle-aged adults, platelet aggregation in the lowest tertile was positively associated with increased amyloid and tau PET uptake in Alzheimer's disease-vulnerable regions.
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