January 14, 2014Annual Review of Medicine
The Antithrombotic Effects of Statins
Key result
Statins reduce thrombosis via multiple pathways, including inhibiting platelet activation and reducing tissue factor expression, likely contributing to reduced cardiovascular death.
Why the study?
Do statins exert antithrombotic effects independent of their lipid-lowering properties?
Design
Review
Authors
Discussion
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Member takes
Implication
Supports pleiotropic antithrombotic effects; leaves open independence from lipid lowering in prospective trials.
Structured PICO
Do statins exert antithrombotic effects independent of their lipid-lowering properties?
I
Intervention
Statins
O
Outcome
Reduction of thrombosis
Statins exert pleiotropic antithrombotic effects that likely contribute to their ability to reduce cardiovascular death.
Cite This Study
Owens et al. (2014) conducted a review in Hypercholesterolemia. Statins was evaluated. Statins reduce thrombosis via multiple pathways, including inhibiting platelet activation and reducing tissue factor expression, likely contributing to reduced cardiovascular death.