Key result
Non-obese children with migraine had significantly increased epicardial adipose tissue thickness compared to healthy controls (6.32 mm vs 3.73 mm, p<0.001), indicating early subclinical atherosclerosis.
Why the study?
To evaluate epicardial adipose tissue thickness and carotid intima-media thickness to detect the link between migraine and increased cardiovascular event risk in children, independent of traditional risk factors.
Is migraine associated with increased epicardial adipose tissue thickness and carotid intima-media thickness in non-obese children?
Case-Control (n=92)
Single-blind
No
Is migraine associated with increased epicardial adipose tissue thickness and carotid intima-media thickness in non-obese children?
In non-obese children with migraine, significantly increased epicardial adipose tissue and carotid intima-media thickness suggest an elevated risk of subclinical atherosclerosis independent of traditional risk factors.
Suggests elevated subclinical atherosclerosis risk in pediatric migraine; leaves open causal confirmation and screening utility in cohorts.
Objective: Epicardial adipose tissue is an important predictive factor of incident cardiovascular events independent from the plasma concentration of circulating biomarkers as well as patient's traditional risk factors. In our study, we aimed to evaluate both epicardial adipose tisssue thickness and carotid intima-media thickness to detect the link between migraine and the increased risk of cardivascular events in children with migraine, independent from traditional risk factors like obesity, high serum lipid and conventional C-reactive protein levels. Methods: Forty-five migraine patients and 47 age, and gender-matched healthy children were assesed. regarding carotid intima media and epicardial adipose tissue thickness parameters measured by echocardiography were compared between two groups. Results: No significant difference was detected in children with migraine and control group in terms of serum lipid levels, C-reactive protein levels that are known to be related with coronary vascular changes between two groups. The statistically significant difference was found in carotid intima media and epicardial adipose tissue thickness values between the study and control groups (p<0.001). A significantly positive correlation was found between carotid intima media and epicardial adipose tissue thickness values in migraine group.
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Tosun et al. (2019) conducted a case-control in Migraine (n=92). Migraine vs. Healthy controls was evaluated on Epicardial adipose tissue thickness (mm) (p=<0.001). Non-obese children with migraine had significantly increased epicardial adipose tissue thickness compared to healthy controls (6.32 mm vs 3.73 mm, p<0.001), indicating early subclinical atherosclerosis.
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