Synthesis and Biological Activity of Sterically Hindered Phenolic Derivatives of Phosphorylacetic Acid Hydrazides

The synthesis of new acylhydrazones based on derivatives of phosphorylacetic acids and 2,3-dihydroxybenzaldehyde was performed. Their antibacterial and cytotoxic activity was studied. Many of the prepared compounds surpass sorafenib in activity against M-HeLa cells. 2-Chloroethyl (E)-(4-diethylaminophenyl)-{2-[2-(2,3-dihydroxy-4,6-dicyclohexylbenzylidene)hydrazinyl]-2-oxoethyl}phosphinate showed selectivity towards tumor cells. The relationship between lipophilicity and antitumor effect was revealed. The results confirm the promise of the obtained acylhydrazones as potential selective antitumor agents.