Key result
Every 0.05 lower normalized grip strength was independently associated with increased odds of diabetes, cardiometabolic disease, and physical disability.
Why the study?
Is low normalized grip strength associated with increased risk of cardiometabolic disease and physical disability in middle-aged and older adults?
Cross-Sectional (n=10,574)
Yes
Is low normalized grip strength associated with increased risk of cardiometabolic disease and physical disability in middle-aged and older adults?
Low normalized grip strength is a robust biomarker associated with higher odds of cardiometabolic disease and physical disability in aging populations in the U.S. and China.
Answers are grounded in this paper and cite their sources.
Normalized grip strength may aid geriatric risk screening; leaves open prospective validation and causality.
BACKGROUND: Evidence highlights the importance of muscular strength as a protective factor for health and function across aging populations. The purpose of this study was to examine the extent to which low normalized grip strength (NGS) serves as a biomarker for both cardiometabolic disease and physical disability in U.S. and Chinese adults. METHODS: Middle aged and older adults from the U.S. National Health and Nutrition Examination Survey 2011-2012 and 2013-2014 combined surveys (n = 4,544), and the 2011 wave of the China Health and Retirement Longitudinal Study (n = 6,030) were included. Strength was assessed using a handgrip dynamometer, and was normalized to body mass. Weighted logistic regression models were used to assess the association between NGS and diabetes, hyperglycemia, hypertriglyceridemia, low HDL-cholesterol, hypertension, and physical disability status, while controlling for age, sex, and sociodemographic characteristics. RESULTS: Every 0.05 lower NGS was independently associated with a 1.49 (95% confidence interval [CI]: 1.42-1.56) and 1.17 (95% CI: 1.11-1.23) odds for diabetes; a 1.46 (95% CI: 1.39-1.53) and 1.11 (95% CI: 1.07-1.15) odds of hyperglycemia; a 1.15 (95% CI: 1.07-1.25) and 1.11 (95% CI: 1.08-1.14) odds of hypertriglyceridemia; a 1.22 (95% CI: 1.17-1.27) and 1.15 (95% CI: 1.12-1.18) odds of low HDL-cholesterol; a 1.19 (95% CI: 1.14-1.24) and 1.10 (95% CI: 1.07-1.14) odds of hypertension; and a 1.36 (95% CI: 1.29-1.42) and 1.10 (95% CI: 1.05-1.15) odds for physical disability status in U.S. and Chinese adults, respectively. CONCLUSIONS: NGS was robustly associated with both cardiometabolic disease risk and physical disabilities in U.S. and Chinese aging adults.
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Peterson et al. (2017) conducted a cross-sectional in Cardiometabolic disease and physical disabilities (n=10,574). Low normalized grip strength (NGS) was evaluated on Diabetes (per 0.05 lower NGS in U.S. adults) (OR 1.49, 95% CI 1.42-1.56). Every 0.05 lower normalized grip strength was independently associated with increased odds of diabetes, cardiometabolic disease, and physical disability.
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