Demonstrates improvement in autoimmune pancreatitis symptoms in a Crohn's disease patient, indicating effective treatment options.
Autoimmune pancreatitis (AIP) is an uncommon immune-mediated condition that can mimic pancreatic cancer and present with obstructive jaundice. Type 2 AIP is IgG4-independent and commonly associated with inflammatory bowel disease. We describe a woman with Crohn's disease who presented with abdominal pain, jaundice, and cholestatic liver injury. Imaging showed pancreatic head enlargement and biliary strictures concerning for malignancy. Initial biopsy and serology were inconclusive with normal immunoglobulin subclass 4 levels. Endoscopic ultrasound demonstrated chronic pancreatic inflammation, and corticosteroid therapy led to marked improvement, supporting a diagnosis of type 2 AIP complicated by secondary sclerosing cholangitis and type 3c diabetes.
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Husain et al. (2026) studied this question.
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