Case report identifies obstructive jaundice in a male with autoimmune pancreatitis, suggesting diagnostic challenges.
Type 1 autoimmune pancreatitis is a fibroinflammatory condition within the immunoglobulin G4 (IgG4)-related disease spectrum, characterized by lymphoplasmacytic infiltration, storiform fibrosis, and elevated serum IgG4 levels.It represents a significant diagnostic challenge due to its frequent radiologic and clinical overlap with pancreaticobiliary malignancies.We describe the case of a 70-year-old male who developed obstructive cholestasis after endoscopic treatment for choledocholithiasis.Multimodal imaging, including endoscopic retrograde cholangiopancreatography, magnetic resonance cholangiopancreatography, and positron emission tomography-computed tomography, showed biliary strictures, a pancreatic head mass, and metabolically active lymphadenopathy.Histopathologic confirmation through endoscopic ultrasound-guided biopsy, along with serologic results, established the diagnosis.Early corticosteroid therapy resulted in significant biochemical and radiologic improvement.
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López-Méndez et al. (2026) studied this question.
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