PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
May 28, 2026Annual Review of Biomedical Data Science

Modeling the Language of Codons with Artificial Intelligence

View Full Paper
Ask AI
Bookmark
Share

Authors

CLClaudèle Lemay-St-DenisRKRachel Kolodny

Discussion

Loading...

Member takes

Overview

Review highlights AI models for codon sequences, focusing on prediction and protein design applications.

Key Points

  • This review aims to summarize progress in artificial intelligence models operating at the codon level and their applications in protein expression and molecular evolution.
  • Summarizes advancements in codon-level AI models, including both discriminative and generative approaches.
  • Discusses applications of codon language models for downstream prediction tasks and protein design.
  • Highlights studies that utilize codon-based AI to understand molecular evolution.
  • Identifies statistical patterns in codon usage that influence mRNA stability and translation efficiency.
  • Demonstrates the use of generative models for optimizing codon sequences to enhance protein expression.
  • Outlines existing challenges and opportunities in the field of codon-based AI models.

Cite This Study

Lemay-St-Denis et al. (2026) studied this question.

synapsesocial.com/papers/6a17dc233fad632b0f9d8d5chttps://doi.org/10.1146/annurev-biodatasci-092624-105741
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Specific codons control cellular resources and fitness2024 · 15 citations
  2. 2The stop-and-go traffic regulating protein biogenesis: How translation kinetics controls proteostasis2018 · 185 citations
  3. 3Bacteriophage T4 Genome2003 · 849 citations
  4. 4Codon catalog usage and the genome hypothesis1980 · 810 citations
  5. 5Revisiting the codon adaptation index from a whole-genome perspective: analyzing the relationship between gene expression and codon occurrence in yeast using a variety of models2003 · 163 citations