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Shows that ubiquitination defects increase invasive fungal pneumonia susceptibility, suggesting new therapeutic targets.
Programmed cell death and systematic protein degradation as exemplified by apoptosis and ubiquitination respectively, are essential biological processes for homeostasis and cellular regeneration. We show that dysregulated ubiquitination and aggravated apoptosis resulting from hypomorphic X-linked Inhibitor of Apoptosis Protein gene mutation suppressed innate immunity, predisposing to human invasive fungal pneumonia.
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Tan et al. (2026) studied this question.
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