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This review explores the relevance of animal models in representing the symptom diversity of Parkinson’s disease.
• Parkinson’s disease is a multisystem disease with a complex symptomatology. • Rodent PD models are created by toxins, viral vectors, and genetic manipulation. • α-synuclein-based models mimic major histopathological and behavioral PD hallmarks. • Neuromelanin-based models are promising tools to study multiple PD-related aspects.
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Cenere et al. (2026) studied this question.
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