Formulation and Characterization of Cyclodextrin Based Complex for Poorly Soluble Phytoconstituents

Quercetin, a flavonoid has high therapeutic potential but it's bioavailability is very less, it alsohas poor solubility in water. An attempt was made in this study to improve the solubility anddissolution of Quercetin by using Lycoat RS 720 and hydroxypropyl--cyclodextrin (HP--CD).The complexes were prepared using the solvent evaporation method. In vitro dissolution studyof formulation and study on the concentration of drug and saturation solubility were performed.Techniques like FTIR, DSC, XRD, UV were performed to confirm the complexation and tostudy their behavior. It was confirmed that the complex formed was between quercetin and HP--CD and it also had improved solubility and better dissolution rate compared to pure quercetin.Lycoat RS 720 was used to improve the stability and dispersion of the complex. The decreasein crystallinity shows that there was a release of better drug release. This work therefore offersa useful way to increase bioavailability.