Guanidine-Based Azines from N-Heterocyclic Carbene (NHC)-Derived Selenoureas and Diazo Compounds: Synthesis, Structural Diversification, and Biological Evaluation

Q: What does this research mean for the field?

Guanidine-based azines can be successfully synthesized via the reaction of N-heterocyclic carbene (NHC)-derived selenoureas and diazo compounds, enabling structural diversification for biological evaluation. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Dimitrios K. Giannopoulos; Ilias Papantzimas; Spyridon A. Ferikoglou; Efstathios Tonis; Nikolaos V. Tzouras; Athanasios Pseftogas; Fady Nahra; Steven P Nolan; Aristides G. Eliopoulos; Georgios C. Vougioukalakis

doi:10.1039/d6ob00548a

January 1, 2026Organic & Biomolecular ChemistryOpen Access

Guanidine-Based Azines from N-Heterocyclic Carbene (NHC)-Derived Selenoureas and Diazo Compounds: Synthesis, Structural Diversification, and Biological Evaluation

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Key Points

The aim is to synthesize guanidine-based azines and evaluate their biological properties.
Synthesis of guanidine-based azines via reactions involving N-heterocyclic carbenes, selenoureas, and diazo compounds.
Structural diversification techniques were applied to explore variations in molecular configurations.
Biological evaluation to assess the medicinal potential of synthesized compounds.
Successfully synthesized a variety of guanidine-based azines.
Demonstrated promising biological activity, indicating potential therapeutic applications.
Structural diversity was achieved through multiple synthetic routes, enhancing compound library.

Implication

Demonstrates the synthesis and biological evaluation of guanidine-based azines from selenoureas, indicating their potential in medicinal chemistry.

Abstract

Guanidine-based azines combine two functional groups in their structure, both of which are widely encountered in medicinal chemistry. Such molecules are accessible, among others, via the versatile reaction of N-heterocyclic...

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Cite This Study

Giannopoulos et al. (2026) studied this question.

synapsesocial.com/papers/6a17dcdf3fad632b0f9d993f https://doi.org/10.1039/d6ob00548a

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Guanidine-Based Azines from N-Heterocyclic Carbene (NHC)-Derived Selenoureas and Diazo Compounds: Synthesis, Structural Diversification, and Biological Evaluation

Key Points

Implication

Abstract

Discussion

Cite This Study

Guanidine-Based Azines from N-Heterocyclic Carbene (NHC)-Derived Selenoureas and Diazo Compounds: Synthesis, Structural Diversification, and Biological Evaluation

Key Points

Implication

Abstract

Discussion

Cite This Study

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