Design, synthesis, in-silico and in-vitro evaluation of Novel Complex Naphthalimide-Ciprofloxacin Hybrids as next-generation antimicrobial agents

Q: What does this research mean for the field?

Novel ciprofloxacin-naphthalimide hybrid compounds exhibit antibacterial activity against both gram-positive and gram-negative bacterial strains, including drug-resistant clinical isolates. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Arunava Manna; Dharmendra singh; Ankita Singh; Harikesh Kumar Gupta; Sajida Banoo; Sumit Maurya; Vishwakarma Krishna Ramesh; Khushbu Khushbu; Ambrish Kumar; Jyoti Kumari; Avisek Mahapa; Shruti Trivedi; Rajnish Kumar; Shashikala Verma

doi:10.1039/d6md00193a

January 1, 2026RSC Medicinal Chemistry

Design, synthesis, in-silico and in-vitro evaluation of Novel Complex Naphthalimide-Ciprofloxacin Hybrids as next-generation antimicrobial agents

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Key Points

The aim is to design and assess novel ciprofloxacin-naphthalimide hybrid drugs for antibacterial activity.
Synthesis of ciprofloxacin-naphthalimide hybrids
In-silico evaluation for antibacterial properties
In-vitro screening against drug-resistant bacterial strains
The hybrids demonstrated significant antibacterial activity against both gram-positive and gram-negative bacteria.
Minimum inhibitory concentrations for the hybrids were significantly lower than those of ciprofloxacin alone.
These findings indicate the potential of hybrids as effective alternatives to traditional antibiotics.

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Implication

Evaluates antibacterial properties of naphthalimide-ciprofloxacin hybrids, suggesting potential as new treatments.

Abstract

A series of ciprofloxacin-naphthalimide hybrid drugs as novel antibacterial agents were synthesized and screened for their antibacterial property against gram-positive and gram-negative bacterial strains, including drug-resistant clinical isolates. Minimum inhibitory...

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Manna et al. (2026) studied this question.

synapsesocial.com/papers/6a17dcf93fad632b0f9d9b65 https://doi.org/10.1039/d6md00193a

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Design, synthesis, in-silico and in-vitro evaluation of Novel Complex Naphthalimide-Ciprofloxacin Hybrids as next-generation antimicrobial agents

Key Points

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Implication

Abstract

Discussion

Cite This Study

Design, synthesis, in-silico and in-vitro evaluation of Novel Complex Naphthalimide-Ciprofloxacin Hybrids as next-generation antimicrobial agents

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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