Ailtozin: Discovery of FGF21-p44, a Human-Specific +1 Frameshifted Microprotein with Stable Alpha-Helical Structure and FGF21-Mimetic Potential

Key Points

• This research focuses on the identification of FGF21-p44, a novel microprotein linked to metabolic health.
• Utilized AlphaFold2 to predict the structural stability of the microprotein.
• Identified the microprotein through a +1 frameshift mutation in the human FGF21 gene.
• FGF21-p44 is a 44-amino acid microprotein with a predicted stable alpha-helical structure.
• Establishes Ailtozin as a previously undescribed molecule with potential applications in treating metabolic diseases.