Emerging applications of traditional and generative artificial intelligence in Liver Transplantation

Artificial intelligence (AI) has emerged as a transformative force in liver transplantation (LT), spanning patient selection, donor-recipient matching, intraoperative management, and post-transplant care. Historically, applications have relied on traditional machine learning (ML) and deep learning (DL) techniques trained on structured clinical datasets to improve risk stratification and outcome prediction. Since 2023, however, advances in generative AI (GenAI) and large language models (LLMs) have expanded the scope of AI in LT, enabling multimodal reasoning and extraction of clinically meaningful information from unstructured data. This review synthesizes recent AI-driven developments across the LT patient journey, from advanced chronic liver disease management to long-term post-transplant outcomes. Representative applications include ML-based models to optimize treatment selection and waitlist prioritization for hepatocellular carcinoma, random forest and gradient boosting approaches to improve donor utilization and predict graft survival, and DL-based imaging models for graft volumetry and steatosis assessment. Post-transplant innovations encompass neural network models for graft injury classification, recurrent architectures for immunosuppression dosing and fibrosis prediction, multitask frameworks for complication risk stratification, and integrative omics-based approaches to detect rejection and dysfunction. Emerging GenAI applications include LLM-enabled digital phenotyping of social determinants of health and multi-agent simulations of transplant selection committees. Despite rapid progress, translation into routine practice remains limited by challenges in local validation, workflow integration, and infrastructure requirements. Future opportunities lie in incorporating underutilized data domains, such as psychosocial factors, -omics, and intraoperative physiologic streams, and leveraging GenAI to enhance clinical decision support, research scalability, and patient–clinician communication. AI is poised not only to refine prediction, but to reshape the conceptual and operational landscape of liver transplantation.