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February 1, 2025Journal of Public HealthOpen Access

Loneliness and social isolation correlate with multiple modifiable risk factors for chronic diseases including dementia

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Key result

Social isolation and loneliness are linked to high risk on seven of nine modifiable health factors.

  • n=6,670

Why the study?

Loneliness and social isolation are risk factors for chronic diseases including dementia, but the pathways of influence are not yet clear.

Population

6670 cohort study survey participants (mean age 63 years)

Comparison

Higher social isolation and loneliness vs lower levels across modifiable health risk factors

Design

Cohort study survey analysis

Authors

LBLarissa BartlettHFHannah FairABAidan Bindoff

Discussion

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Overview

May support screening for isolation in patients with multiple risk factors; leaves open causality and intervention effects.

Study Design

Type

Cross-Sectional (n=6,670)

Structured PICO

P
Population
6,670 adults aged 50 years or older resident in Tasmania, Australia, mean age 63.6 years, 71.5% female.
O
Outcome
Levels of risk for nine modifiable health risk factors (cholesterol, smoking, physical activity, BMI, diabetes management, cognitive activity, alcohol consumption, hypertension management, diet)

Social isolation and loneliness are differentially associated with modifiable health risk factors, suggesting that targeted interventions may be needed to address specific behavioral and cardiometabolic risks.

Limitations

  • Causality cannot be concluded from cross-sectional data
  • Loneliness was not assessed using a validated research questionnaire for this construct
  • Depression is an established determinant of both chronic disease and dementia but was not included in this study

Cite This Study

Bartlett et al. (2025) conducted a cross-sectional in Modifiable risk factors for chronic diseases and dementia (n=6,670). Social isolation and loneliness was evaluated on High-risk status on nine modifiable health risk factors (Dementia Risk Profile). Higher social isolation and loneliness were significantly associated with high-risk status on seven of nine modifiable health risk factors for chronic diseases and dementia.

synapsesocial.com/papers/6a17dfbfa0e670aec86edaa6https://doi.org/10.1007/s10389-025-02412-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Social isolation and loneliness as modifiable risk factors for dementia: Evidence-based interventions and public health implications2025 · 5 citations
  2. 2Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality2021 · 168 citations
  3. 3Social isolation, social support, loneliness and cardiovascular disease risk factors: A cross‐sectional study among older adults2021 · 72 citations
  4. 4Loneliness, social isolation and cardiovascular risk2019 · 24 citations
  5. 5Relationship between loneliness, social isolation and modifiable risk factors for cardiovascular disease: a latent class analysis2021 · 29 citations