Key result
Matrix metalloproteinase 2 (MMP-2) was a strong predictor of HF-PEF (AUC 0.91; 95% CI 0.84-0.98; P<0.01), yielding 91% sensitivity and 76% specificity at a cutoff of 1585 ng/mL.
Why the study?
Do serological markers of collagen turnover improve the diagnostic accuracy of HF-PEF and DD compared to BNP in treated hypertensive patients?
Population
85 Caucasian treated hypertensive patients (DD n=65; both DD and HF-PEF n=32)
Comparison
Measurement of serological markers of collagen… vs B-type natriuretic peptide (BNP)
Design
Cross-sectional
Authors
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May aid HF-PEF diagnosis in hypertensives; hypothesis-generating versus BNP, needing prospective validation.
Observational (n=85)
Do serological markers of collagen turnover improve the diagnostic accuracy of HF-PEF and DD compared to BNP in treated hypertensive patients?
Effect estimate: AUC 0.91 (95% CI 0.84-0.98)
p-value: p=<0.01
Markers of collagen turnover, particularly MMP-2, may offer improved diagnostic accuracy over BNP for identifying HF-PEF in hypertensive patients.
Martos et al. (2009) conducted an observational in Heart failure with preserved ejection fraction (HF-PEF) and diastolic dysfunction (n=85). Serological markers of collagen turnover (MMP-2) vs. B-type natriuretic peptide (BNP) was evaluated on Prediction of HF-PEF (AUC 0.91, 95% CI 0.84-0.98, p=<0.01). Matrix metalloproteinase 2 (MMP-2) was a strong predictor of HF-PEF (AUC 0.91; 95% CI 0.84-0.98; P<0.01), yielding 91% sensitivity and 76% specificity at a cutoff of 1585 ng/mL.
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