What question did this study set out to answer?

To evaluate the prognostic capacity of circulating growth differentiation factor-15 (GDF-15) for predicting adverse 30-day outcomes and long-term mortality in patients with acute pulmonary embolism.

February 8, 2008American Journal of Respiratory and Critical Care Medicine

Growth Differentiation Factor-15 for Prognostic Assessment of Patients with Acute Pulmonary Embolism

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Authors

MLMareike LankeitGeneral Cardiology TKTibor KempfBoston University CDClaudia DellasPediatric Cardiology

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Implication

Prospective cohort study demonstrates that elevated GDF-15 predicts short- and long-term complications in acute pulmonary embolism, indicating its utility for risk stratification.

Key Points

To evaluate the prognostic capacity of circulating growth differentiation factor-15 (GDF-15) for predicting adverse 30-day outcomes and long-term mortality in patients with acute pulmonary embolism.
Conducted a prospective cohort study measuring admission plasma GDF-15 levels via immunoradiometric assay in 123 consecutive patients with confirmed acute pulmonary embolism.
Assessed 30-day complication rates and long-term mortality using multivariable logistic and Cox regression models adjusted for clinical features, cardiac troponin T, NT-proBNP, and echocardiography.
Patients experiencing 30-day complications had significantly higher baseline GDF-15 levels (median 6,039 ng/L) than uncomplicated patients (median 2,036 ng/L; P < 0.001), remaining an independent predictor in multivariable analysis (P = 0.033).
GDF-15 showed superior discriminatory accuracy for 30-day complications (c-statistic 0.84, 95% CI 0.76–0.90) compared to cardiac troponin T (0.72) and NT-proBNP (0.65).
Baseline GDF-15 independently predicted long-term mortality in multivariable Cox regression (P < 0.001) and enhanced the prognostic performance of standard biomarkers and echocardiographic markers.

Cite This Study

Lankeit et al. (2008) studied this question.

synapsesocial.com/papers/6a17e77756b3e2ada412c71a https://doi.org/10.1164/rccm.200712-1786oc

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Implication

Prospective cohort study demonstrates that elevated GDF-15 predicts short- and long-term complications in acute pulmonary embolism, indicating its utility for risk stratification.

Growth Differentiation Factor-15 for Prognostic Assessment of Patients with Acute Pulmonary Embolism

Discussion

Member takes

Implication

Key Points

Cite This Study

Growth Differentiation Factor-15 for Prognostic Assessment of Patients with Acute Pulmonary Embolism

Discussion

Member takes

Implication

Key Points

Cite This Study

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