Key result
Higher CK linked to ~6-fold greater hypertension odds per log increase, via increased vascular resistance.
Why the study?
Creatine kinase is thought to affect hemodynamics through enhanced systemic vascular resistance, stroke volume, and cardiac contractility, but data on these parameters are lacking.
Does higher resting plasma creatine kinase associate with increased blood pressure and cardiovascular hemodynamics in a multiethnic adult population?
Population
14 937 men and women in the multiethnic HELIUS study
Comparison
Hemodynamics across resting plasma CK levels
Design
Cross-sectional study
Authors
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Higher CK should not yet change hypertension practice; leaves open causal role and need for prospective validation.
Cross-Sectional (n=14,937)
No
Does higher resting plasma creatine kinase associate with increased blood pressure and cardiovascular hemodynamics in a multiethnic adult population?
Effect estimate: OR 6.1 (95% CI 5.1-7.2)
Resting plasma creatine kinase is strongly and independently associated with higher blood pressure, systemic vascular resistance, and stroke volume in a multiethnic population.
Brewster et al. (2020) conducted a cross-sectional in Hypertension (n=14,937). Creatine kinase (CK) levels vs. Lower CK levels was evaluated on Hypertension (per log CK increase) (OR 6.1, 95% CI 5.1-7.2). Higher resting plasma creatine kinase levels were associated with increased blood pressure and a 6.1-fold greater odds of hypertension per log CK increase, likely due to increased systemic vascular resistance and stroke volume.
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