LHRH, LH-releasing hormone; MA, megestrol acetate; PC, prostate cancer; PSA, prostate-specific antigen; SHBG, sex hormone-binding globulin; T, testosterone; TAF, transcriptional activation function.1 AI is defined as prostate cancer progression with castrate levels of testosterone.Hormone refractory prostate cancer is a disease that has progressed after primary castration and second-line therapies such as antiandrogens, adrenal suppression, and estrogens.
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Taplin et al. (2001) studied this question.
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