Key result
Enalapril did not significantly increase overall urinary NTproBNP excretion versus placebo, though a subgroup with increased sodium excretion showed higher NTproBNP excretion (p<0.05).
Why the study?
Does enalapril modulate the renal excretion of NTproBNP in healthy male volunteers?
Population
10 healthy male volunteers on a sodium-enriched diet for 7 days
Comparison
Enalapril plus 20 ml/kg NaCl 0.9% infused over… vs Placebo plus 20 ml/kg NaCl 0.9% infused over 60…
Design
RCT, crossover, double-blind
Follow-up
10 hours on the test day
Authors
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Enalapril does not increase NTproBNP excretion overall in healthy volunteers; leaves open subgroup effects tied to sodium excretion for patient studies.
RCT (n=10)
Double-blind
Crossover
Does enalapril modulate the renal excretion of NTproBNP in healthy male volunteers?
Enalapril may modify the renal excretion of NTproBNP in healthy subjects, particularly those showing an increase in sodium excretion, though the exact mechanism remains unclear.
Heringlake et al. (2006) conducted an RCT in Healthy (n=10). Enalapril vs. Placebo was evaluated on Urinary NTproBNP/creatinine excretion. Enalapril did not significantly increase overall urinary NTproBNP excretion versus placebo, though a subgroup with increased sodium excretion showed higher NTproBNP excretion (p<0.05).
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