Key result
Zero-phase Butterworth filtering at 500 Hz cuts computational load ~50% while matching ECG-derived HRV.
Why the study?
PPG-based HRV offers a cost-effective alternative to ECG for wearable autonomic monitoring, but signal processing needed optimization on a 16-bit microcontroller.
Does zero-phase Butterworth filtering at 500 Hz improve the accuracy of PPG-derived HRV indices compared to ECG standards in healthy adults?
Does zero-phase Butterworth filtering at 500 Hz improve the accuracy of PPG-derived HRV indices compared to ECG standards in healthy adults?
Effect estimate: CCC ≥0.94
Zero-phase Butterworth filtering at 500 Hz provides an optimal balance of accuracy and computational efficiency for PPG-based HRV monitoring in wearable devices.
May support efficient PPG-HRV wearables; hypothesis-generating in small healthy sample, needs larger validation.
Photoplethysmography (PPG)-based heart rate variability (HRV) offers a cost-effective alternative to electrocardiography (ECG) for autonomic monitoring in wearable devices. We optimized signal processing on a 16-bit microcontroller by comparing 4th-order equivalent Butterworth and Elliptic IIR bandpass filters (0.8–20 Hz, zero-phase) at 1000, 500, and 250 Hz. Paired PPG–ECG recordings from 10 healthy adults were analyzed for ln HF, ln LF, and ln VLF using Lin’s concordance correlation coefficient (CCC), ±5% equivalence testing (TOST), and Passing–Bablok regression (PBR). Butterworth at 500 Hz preserved near-identity with ECG standard (CCC ≥0.94; TOST met equivalence; PBR slopes/intercepts: ln HF = 0.97x + 0.10, ln LF = 1.02x − 0.07, ln VLF = 1.01x − 0.03), while halving computational load. In contrast, Elliptic at 250 Hz degraded concordance (CCC ≈ 0.64) and failed equivalence, with greater bias from nonlinear phase and ripple-induced distortion. Elliptic performance improved at higher sampling but offered no benefit over Butterworth. These results support zero-phase Butterworth filtering at ≥500 Hz as the optimal balance of fidelity, robustness, and efficiency, enabling reliable PPG-HRV monitoring on low-power devices. As a pilot investigation (n = 10), this study establishes preliminary design parameters and optimal configurations to guide subsequent large-scale clinical validation.
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Abdrasulova et al. (2025) studied Healthy (n=10). Zero-phase Butterworth filtering at 500 Hz vs. Elliptic filtering and other sampling frequencies (1000 Hz, 250 Hz) was evaluated on Concordance of PPG-derived HRV indices (ln HF, ln LF, ln VLF) with ECG standard (CCC ≥0.94). Zero-phase Butterworth filtering at 500 Hz optimized PPG-based HRV analysis, preserving near-identity with the ECG standard (CCC ≥0.94) while halving computational load.
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