Key result
Rotavirus causes ~28% of viral gastroenteritis in Burkina Faso alongside highly prevalent hepatitis A.
Why the study?
Although studies have assessed enteric viruses in Burkina Faso, no aggregate data on the prevalence and circulating genotypes responsible for human infections had been released.
Meta-Analysis (n=4,214)
This meta-analysis highlights a substantial burden of viral enteric infections in Burkina Faso, predominantly driven by rotavirus and hepatitis A, underscoring the need for improved preventive measures.
Supports prioritizing rotavirus vaccination in Burkina Faso; leaves open generalizability to other regions.
BACKGROUND: Viruses, which are transmitted mainly via the digestive tract, are responsible for the high morbidity and mortality of diseases, particularly in low-income countries. Although several studies have established the prevalence and characterization of various enteric viruses in Burkina Faso, to date, no aggregate data have been released. OBJECTIVE: Our objective was to describe the available data on the prevalence and circulating genotypes of enteric pathogen viruses responsible for human infections in Burkina Faso by carrying out a systematic review and meta-analysis. METHODS: Potentially relevant studies were identified by a search of PubMed, ScienceDirect, Google Scholar, university libraries and by a manual search of the reference lists of identified studies. The search with no restrictions on language or age was limited to studies conducted only in Burkina. Study selection, data extraction, and methodological quality of the included studies were performed independently by two investigators. Heterogeneity between studies was assessed using the Cochrane Q test and I2 test statistics based on the random effects model. Comprehensive meta-analysis (CMA 3.7) was employed to compute the pooled prevalence of pathogens identified in the studies. RESULTS: Forty-three (43) studies reporting 4,214 diagnosed cases in all aged human populations were selected. Overall, 72.6% of the pathogens diagnosed were gastroenteritis, and 27.2% were entero-transmissible hepatitis viruses. Rotavirus was the most common cause of human viral gastroenteritis, accounting for 27.7% (95% CI: 20.9 - 35.8) of the cases, followed by norovirus (16% (95% CI: 12.25 - 20.6)) and sapovirus (11.2% (95% CI: 6.2 - 19.4)). In terms of human entero-transmissible infections, hepatitis A virus (HAV) was the most prevalent (52% [95% CI: 14.2-87.7] of total antibodies), followed by hepatitis E virus (HEV) (28.3% [95% CI: 17.7-42]). CONCLUSIONS: This study highlights the substantial burden of viral enteric infections and highlights the need for more molecular epidemiological studies to improve preventive measures against these viruses.
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Traoré et al. (2024) conducted a meta-analysis in Enteric viral infections (gastroenteritis and hepatitis) (n=4,214). Prevalence of enteric viruses was evaluated on Pooled prevalence of rotavirus in human viral gastroenteritis (95% CI 20.9 - 35.8). Rotavirus was the most common cause of human viral gastroenteritis in Burkina Faso, accounting for 27.7% of cases, while hepatitis A virus was the most prevalent entero-transmissible infection at 52%.
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