What question did this study set out to answer?

To assess the duration and waning patterns of natural immunity and hybrid immunity compared with vaccine-induced immunity against SARS-CoV-2 reinfection.

May 25, 2022New England Journal of MedicineOpen Access

Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2

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Authors

YGYair GoldbergTechnion – Israel Institute of Technology MMMicha MandelHebrew University of Jerusalem YBYinon M. Bar‐OnCalifornia Institute of Technology

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Implication

Cohort study demonstrates waning SARS-CoV-2 immunity across infected and vaccinated individuals, indicating that post-infection vaccination provides superior protection.

Key Points

To assess the duration and waning patterns of natural immunity and hybrid immunity compared with vaccine-induced immunity against SARS-CoV-2 reinfection.
Extracted population-level data from the Israeli Ministry of Health database during August and September 2021, when the delta variant predominated.
Used Poisson regression with adjustment for confounders to evaluate SARS-CoV-2 infection rates by time elapsed since infection, vaccination (BNT162b2), or both.
Among unvaccinated recovered individuals, the adjusted rate of infection per 100,000 person-days rose from 10.5 at 4 to <6 months to 30.2 at ≥1 year post-infection.
Among previously infected individuals who received a single vaccine dose, the adjusted rate increased from 3.7 at <2 months to 11.6 at ≥6 months post-vaccination.
Among uninfected individuals who received two doses of BNT162b2, the adjusted rate rose from 21.1 at <2 months to 88.9 at ≥6 months post-vaccination.

Cite This Study

Goldberg et al. (2022) studied this question.

synapsesocial.com/papers/6a181d1a40149b897cb4a423 https://doi.org/10.1056/nejmoa2118946

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Implication

Cohort study demonstrates waning SARS-CoV-2 immunity across infected and vaccinated individuals, indicating that post-infection vaccination provides superior protection.

Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2

Discussion

Member takes

Implication

Key Points

Cite This Study

Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2

Discussion

Member takes

Implication

Key Points

Cite This Study

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