Key result
DBA/2J mice show no hypertrophic cardiomyopathy over 12 months, supporting use in genetic modeling.
Why the study?
Use of the DBA/2J background for modeling cardiac aspects of Duchenne muscular dystrophy faced criticism based on speculation that it displays an inherent hypertrophic cardiomyopathy phenotype.
Population
DBA/2J mice
Comparison
DBA/2J mice vs age-matched C57/BL10 mice, sedentary vs exercised, and comparisons to canine and human samples
Design
Longitudinal preclinical study
Follow-up
12-month period
Authors
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Supports DBA/2J as clean background strain for genetic cardiomyopathy models; challenges prior reports of spontaneous pathology.
The DBA/2J mouse strain does not spontaneously develop hypertrophic cardiomyopathy, validating its use as a background strain for genetic models of cardiomyopathy such as Duchenne muscular dystrophy.
Hart et al. (2022) studied Hypertrophic cardiomyopathy model evaluation. DBA/2J genetic background vs. C57BL/10 genetic background was evaluated on Echocardiographic and histological signs of hypertrophic cardiomyopathy. The DBA/2J mouse strain showed no evidence of hypertrophic cardiomyopathy or other cardiac pathology over 12 months, indicating it is an appropriate background strain for genetic modeling of cardiac diseases.
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