Key result
The presence of an eight-residue N-terminal extension in mouse cardiac myosin-binding protein C reduced cardiac myosin binding by 60% compared to human protein lacking this extension.
Population
Mouse and human cardiac myosin-binding protein C (cMyBP-C) sequences and recombinant proteins
Comparison
Mouse cMyBP-C containing an eight-residue… vs Human cMyBP-C lacking the N-terminal extension
Design
Preclinical
Authors
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Mouse cMyBP-C N-terminal differences require caution extrapolating binding data from rodent HCM models; leaves open human-specific validation.
The eight-residue N-terminal extension present in mouse but not human cMyBP-C significantly reduces myosin binding, highlighting a critical species difference that must be accounted for in hypertrophic cardiomyopathy models.
Bunch et al. (2018) studied Hypertrophic cardiomyopathy. N-terminal extension (NTE) in mouse cMyBP-C vs. Human cMyBP-C (lacking NTE) was evaluated on Cardiac myosin binding. The presence of an eight-residue N-terminal extension in mouse cardiac myosin-binding protein C reduced cardiac myosin binding by 60% compared to human protein lacking this extension.
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