December 1, 2009Journal of Muscle Research and Cell MotilityOpen Access

Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-C

View Full Paper

Ask AI

Bookmark

Population

cMyBP-C isoforms from different species

Design

Preclinical

Authors

JSJustin F. ShafferColorado School of Mines SHSamantha P. HarrisNewYork–Presbyterian Hospital

Discussion

Member takes

Implication

These cross-species cMyBP-C correlations are hypothesis-generating; should not yet influence clinical practice.

Structured PICO

Population

cMyBP-C isoforms from different species

Intervention

Sequence comparison of the Pro-Ala rich region

Outcome

Number of proline and alanine residues in the Pro-Ala rich region and correlation with mammalian body size and heart rate

Systematic sequence differences in the Pro-Ala rich region of cMyBP-C across species correlate with body size and heart rate, suggesting a role in matching contractile speed to cardiac function.

Cite This Study

Shaffer et al. (2009) studied this question.

synapsesocial.com/papers/6a73eaa3f96a1419040dd9ef https://doi.org/10.1007/s10974-010-9207-8

View Full Paper

Ask AI

Bookmark

Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider