Key result
PKA phosphorylation of cardiac myosin-binding protein C accelerates the kinetics of force development, whereas phosphorylation of cardiac troponin I reduces the calcium sensitivity of force.
PKA phosphorylation of cTnI reduces Ca2+ sensitivity of force, whereas phosphorylation of cMyBP-C accelerates the kinetics of force development, contributing to accelerated relaxation and increased force development rates.
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May explain lusitropic and inotropic effects of adrenergic stress; extends mechanistic insights in animals but leaves open human translation.
Stelzer et al. (2007) studied Cardiac contractility. PKA treatment vs. Wild-type and engineered mouse lines was evaluated on Stretch-activation response and force development kinetics. PKA phosphorylation of cardiac myosin-binding protein C accelerates the kinetics of force development, whereas phosphorylation of cardiac troponin I reduces the calcium sensitivity of force.
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