Why the study?
The functional interactions between the PKC/PKD and PKA phosphorylation sites on cardiac myosin binding protein-C (cMyBP-C) have remained uncharacterized.
Population
Recombinant N-terminal domains of cMyBP-C and in situ functional assays
Comparison
PKC/PKD vs PKA phosphorylation sites on cMyBP-C
Design
In vitro and in situ preclinical experimental study
Authors
Loading...
Phosphorylation mechanisms in myofilaments extend basic cardiac regulation insights; leaves open clinical translation to heart failure therapies.
Identifies a novel functional antagonism between PKC and PKA phosphorylation sites on cMyBP-C, offering a new model for the phosphoregulation of cardiac contractility.
Ponnam et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: