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March 31, 2016Circulation ResearchOpen Access

Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?

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Authors

SHShavonn C. HarperTemple UniversityABAndrew S. BrackDefense Advanced Research Projects AgencySMScott M. MacDonnellRegeneron (United States)

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Harper et al. (2016) studied this question.

synapsesocial.com/papers/6a181df0a0e670aec86f072ehttps://doi.org/10.1161/circresaha.116.307962
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating Growth Differentiation Factor 11/8 Levels Decline With Age2015 · 196 citations
  2. 2GDF11 Does Not Rescue Aging-Related Pathological Hypertrophy2015 · 188 citations
  3. 3Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.1991 · 777 citations
  4. 4Aging Skeletal Muscle: Physiologic Changes and the Effects of Training2002 · 152 citations
  5. 5Favorable left ventricular remodeling following large myocardial infarction by exercise training. Effect on ventricular morphology and gene expression.1995 · 114 citations