Key result
Male sex linked to ~16% higher cIMT in rheumatoid arthritis with low disease activity.
Why the study?
Patients with rheumatoid arthritis (RA) have an excess risk of cardiovascular disease (CVD), but the cardiovascular risk profile between female and male RA patients with low disease activity required comparison.
Do male RA patients with low disease activity have a worse cardiovascular risk profile compared to female RA patients?
Population
70 RA patients with continuous low disease activity and no CVD (54 women, 16 men) and 33 healthy controls
Comparison
Male vs female RA patients
Authors
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May support sex-specific CV monitoring in low-activity RA; hypothesis-generating and requires prospective validation.
Cross-Sectional (n=103)
No
Do male RA patients with low disease activity have a worse cardiovascular risk profile compared to female RA patients?
Absolute Event Rate: 0.93% vs 0.8%
p-value: p=<0.05
Male RA patients with low disease activity exhibit a significantly higher burden of subclinical atherosclerosis and cardiovascular risk compared to females, highlighting the importance of traditional risk factor management in this population.
Targońska‐Stępniak et al. (2019) conducted a cross-sectional in Rheumatoid arthritis with low disease activity (n=103). Male sex vs. Female sex was evaluated on Carotid intima media thickness (cIMT) (p=<0.05). Male rheumatoid arthritis patients with low disease activity exhibited a significantly higher burden of atherosclerosis compared to females, as evidenced by a greater carotid intima media thickness (0.93 mm vs 0.80 mm).
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