Modifiable risk factors incorporating low serum albumin and lipoprotein (a) accounted for up to 92% of the population attributable risk for first incident acute myocardial infarction.
Cross-Sectional (n=7,647)
No
Are modifiable risk factors incorporating lipoprotein (a) and low serum albumin associated with first incident acute myocardial infarction in Chinese patients?
Modifiable risk factors, particularly the combination of low serum albumin and elevated lipoprotein (a), account for a substantial proportion of the population attributable risk for first incident AMI, suggesting new targets for prevention.
Effect estimate: PAR 54% (95% CI 0.48-0.61)
Risk burdens of modifiable risk factors incorporating lipoprotein (a) (Lp(a)) and low serum albumin (LSA) concentrations for first incident acute myocardial infarction (AMI) haven't been studied previously. Cross-sectional study of 1552 cases and 6125 controls was performed for identifying the association of risk factors with first incident AMI and their corresponding population attributable risks (PARs). Modifiable risk factors incorporating LSA and Lp(a) accounted for up to 92% of PAR for first incident AMI. Effects of these risk factors were different in different sexes across different age categories. Overall, smoking and LSA were the 2 strongest risk factors, together accounting for 64% of PAR for first incident AMI. After multivariable adjustment, Lp(a) and LSA accounted for 19% and 41%, respectively, and together for more than a half (54%) of PAR for first incident AMI. Modifiable risk factors incorporating LSA and Lp(a) have accounted for an overwhelmingly large proportion of the risk of first incident AMI, indicating most first incident AMI is preventable. The knowledge of risk burdens for first incident AMI incorporating Lp (a) and LSA may be beneficial for further reducing first incident AMI from a new angle.
Yang et al. (2016) conducted a cross-sectional in First incident acute myocardial infarction (n=7,647). Low serum albumin (LSA) and lipoprotein (a) (Lp(a)) vs. Normal levels was evaluated on Population attributable risk (PAR) for first incident acute myocardial infarction (PAR 54%, 95% CI 0.48-0.61). Modifiable risk factors incorporating low serum albumin and lipoprotein (a) accounted for up to 92% of the population attributable risk for first incident acute myocardial infarction.