Key result
Perivascular fat density is linked to CTA contrast plaque enhancement, especially in symptomatic patients.
Why the study?
Perivascular fat inflammation is linked to high-risk coronary plaques, but its correlation with carotid plaque enhancement on CTA remained unclear.
Does perivascular fat density correlate with contrast plaque enhancement on CTA in patients with carotid artery stenosis?
Observational (n=100)
Does perivascular fat density correlate with contrast plaque enhancement on CTA in patients with carotid artery stenosis?
p-value: p=.001
Perivascular fat density on CTA positively correlates with contrast plaque enhancement, suggesting it could serve as an indirect imaging marker of carotid plaque instability.
May support perivascular fat density as indirect marker of carotid plaque instability; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND AND PURPOSE: Inflammatory changes in the fat tissue surrounding the coronary arteries have been associated with coronary artery disease and high-risk vulnerable plaques. Our aim was to investigate possible correlations between the presence and degree of perivascular fat density and a marker of vulnerable carotid plaque, namely contrast plaque enhancement on CTA. MATERIALS AND METHODS: One-hundred patients (76 men, 24 women; mean age, 69 years) who underwent CT angiography for investigation of carotid artery stenosis were retrospectively analyzed. Contrast plaque enhancement and perivascular fat density were measured in 100 carotid arteries, and values were stratified according to symptomatic (ipsilateral-to-cerebrovascular symptoms)/asymptomatic status (carotid artery with the most severe degree of stenosis). Correlation coefficients (Pearson ρ product moment) were calculated between the contrast plaque enhancement and perivascular fat density. The differences among the correlation ρ values were calculated using the Fisher r-to-z transformation. Mann-Whitney analysis was also calculated to test differences between the groups. RESULTS: value = .001). CONCLUSIONS: There was a positive association between perivascular fat density and contrast plaque enhancement on CTA. This correlation was stronger for symptomatic rather than asymptomatic patients. Our results suggest that perivascular fat density could be used as an indirect marker of plaque instability.
No takes yet. Share an insight, caveat, or question.
Saba et al. (2020) conducted an observational in carotid artery stenosis (n=100). Perivascular fat density measurement vs. Symptomatic vs asymptomatic status was evaluated on Correlation between contrast plaque enhancement and perivascular fat density (p=.001). Perivascular fat density was positively associated with contrast plaque enhancement on CTA, with a stronger correlation in symptomatic versus asymptomatic patients (P=.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: