Key result
BMP-7 shows therapeutic promise across atherosclerosis and MI via potent anti-inflammatory and anti-fibrotic effects.
Why the study?
While rhBMP-7 is used clinically for bone fracture repair, its potential therapeutic use and molecular mechanisms in cardiovascular diseases associated with inflammation remain to be fully characterized.
BMP-7 demonstrates potential therapeutic significance in cardiovascular diseases by modulating inflammation, macrophage polarization, and vascular calcification.
May support therapeutic exploration in atherosclerosis and MI; leaves open clinical translation pending randomized trials.
Bone morphogenetic protein-7 is (BMP-7) is a potent anti-inflammatory growth factor belonging to the Transforming Growth Factor Beta (TGF-β) superfamily. It plays an important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. BMP-7 stimulates the target cells by binding to specific membrane-bound receptor BMPR 2 and transduces signals through mothers against decapentaplegic (Smads) and mitogen activated protein kinase (MAPK) pathways. To date, rhBMP-7 has been used clinically to induce the differentiation of mesenchymal stem cells bordering the bone fracture site into chondrocytes, osteoclasts, the formation of new bone via calcium deposition and to stimulate the repair of bone fracture. However, its use in cardiovascular diseases, such as atherosclerosis, myocardial infarction, and diabetic cardiomyopathy is currently being explored. More importantly, these cardiovascular diseases are associated with inflammation and infiltrated monocytes where BMP-7 has been demonstrated to be a key player in the differentiation of pro-inflammatory monocytes, or M1 macrophages, into anti-inflammatory M2 macrophages, which reduces developed cardiac dysfunction. Therefore, this review focuses on the molecular mechanisms of BMP-7 treatment in cardiovascular disease and its role as an anti-fibrotic, anti-apoptotic and anti-inflammatory growth factor, which emphasizes its potential therapeutic significance in heart diseases.
No takes yet. Share an insight, caveat, or question.
Narasimhulu et al. (2020) conducted a review in Cardiovascular diseases. Bone Morphogenetic Protein 7 (BMP-7) was evaluated. BMP-7 acts as a potent anti-inflammatory, anti-fibrotic, and anti-apoptotic growth factor with potential therapeutic significance in cardiovascular diseases such as atherosclerosis and myocardial infarction.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: